Chorionic Gonadotrophin
- Chorionic Gonadotrophin
- Folignan®
- Solution and Powder for Injection
- 5000 I.U.
- Ampoule
- -
Solvent:
1mL NaCl 0.9% Solution
1mL NaCl 0.9% Solution
• Induction of Ovulation & Pregnancy
• Induction of Spermatogenesis
• Induction of Spermatogenesis
Mechanism of Action
Stimulates production of gonadal steroid hormones by causing production of androgen by the testes
Stimulates ovulation by acting as a substitute for luteinizing hormone
Pharmacokinetics
Excretion: Urine
Contraindications
• Hypersensitivity to drug or components
• Precocious puberty
• Prostatic carcinoma or other androgen-dependent neoplasms
• High serum FSH, indicating primary gonadal failure in women
• Presence of uncontrolled non-gonadal endocrinopathies (eg, thyroid, adrenal, or pituitary disorders)
• Tumors of hypothalamus or pituitary gland and ovary, breast, or uterus in females and breast or prostate in males
• Malformations of reproductive organs incompatible with pregnancy
• Fibroid tumors of uterus incompatible with pregnancy
• Abnormal vaginal bleeding of undetermined origin
Adverse Reactions
Headache, Irritability, Depression, Edema, Restlessness, Gynecomastia, Precocious puberty, Fatigue, Arterial thrombus, Ovarian hyperstimulation syndrome, Ovarian cyst rupture
Major Drug Interactions
-
Warnings
• Administer only after assessing adequate follicular development by serum estradiol & vaginal ultrasonography
Recommendations for Patient
-
Pregnancy Considerations
Category: X
Breastfeeding Considerations
Not known whether this drug is excreted in human milk, because many drugs are excreted in human milk, exercise caution if HCG administered to a nursing woman
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: Maybe acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Stimulates production of gonadal steroid hormones by causing production of androgen by the testes
Stimulates ovulation by acting as a substitute for luteinizing hormone
Pharmacokinetics
Excretion: Urine
Contraindications
• Hypersensitivity to drug or components
• Precocious puberty
• Prostatic carcinoma or other androgen-dependent neoplasms
• High serum FSH, indicating primary gonadal failure in women
• Presence of uncontrolled non-gonadal endocrinopathies (eg, thyroid, adrenal, or pituitary disorders)
• Tumors of hypothalamus or pituitary gland and ovary, breast, or uterus in females and breast or prostate in males
• Malformations of reproductive organs incompatible with pregnancy
• Fibroid tumors of uterus incompatible with pregnancy
• Abnormal vaginal bleeding of undetermined origin
Adverse Reactions
Headache, Irritability, Depression, Edema, Restlessness, Gynecomastia, Precocious puberty, Fatigue, Arterial thrombus, Ovarian hyperstimulation syndrome, Ovarian cyst rupture
Major Drug Interactions
-
Warnings
• Administer only after assessing adequate follicular development by serum estradiol & vaginal ultrasonography
Recommendations for Patient
-
Pregnancy Considerations
Category: X
Breastfeeding Considerations
Not known whether this drug is excreted in human milk, because many drugs are excreted in human milk, exercise caution if HCG administered to a nursing woman
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: Maybe acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
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