Iodixanol
- Iodixanol
- Visodix
- Solution and Powder for Injection
- 320mgI/mL
- Vial
- 50mL
Each 1mL Contains:
Iodixanol 652mg
Equivalent to 320mg Iodine
Iodixanol 652mg
Equivalent to 320mg Iodine
• Arteriography
• IA-DSA
• CECT of head or body
• Excretory urography
• Venography
• IA-DSA
• CECT of head or body
• Excretory urography
• Venography
Mechanism of Action
Dimeric, isosmolar, nonionic, water-soluble, iodinated x-ray contrast agent for intravascular administration, opacifies vessels within path of flow, thereby permitting radiographic visualization of internal structures until significant dilution and elimination occurs
Pharmacokinetics
Peak plasma time: Immediate, 15-120 sec (peak enhancement), 5-15 min (optimum renal contrast), up to 1 hr (brain contrast)
Excretion: 97% excreted unchanged in urine within 24 hr
Contraindications
• Hypersensitivity to product or components
• Intrathecal use
• In children, prolonged fasting and use of laxative before administration is contraindicated
Adverse Reactions
Discomfort at injection site, Angina pectoris, Chest pain, Headache, Migraine, Vertigo, Paresthesia, Pruritus, Skin rash, Erythema, Dysgeusia
Major Drug Interactions
-
Warnings
• Not for intrathecal (IT) use
Recommendations for Patient
• Maintain adequate hydration
Pregnancy Considerations
Category: B
Breastfeeding Considerations
Intravenous iodinated contrast media are poorly excreted into breastmilk and poorly absorbed orally so they are not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants.
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: Maybe acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Dimeric, isosmolar, nonionic, water-soluble, iodinated x-ray contrast agent for intravascular administration, opacifies vessels within path of flow, thereby permitting radiographic visualization of internal structures until significant dilution and elimination occurs
Pharmacokinetics
Peak plasma time: Immediate, 15-120 sec (peak enhancement), 5-15 min (optimum renal contrast), up to 1 hr (brain contrast)
Excretion: 97% excreted unchanged in urine within 24 hr
Contraindications
• Hypersensitivity to product or components
• Intrathecal use
• In children, prolonged fasting and use of laxative before administration is contraindicated
Adverse Reactions
Discomfort at injection site, Angina pectoris, Chest pain, Headache, Migraine, Vertigo, Paresthesia, Pruritus, Skin rash, Erythema, Dysgeusia
Major Drug Interactions
-
Warnings
• Not for intrathecal (IT) use
Recommendations for Patient
• Maintain adequate hydration
Pregnancy Considerations
Category: B
Breastfeeding Considerations
Intravenous iodinated contrast media are poorly excreted into breastmilk and poorly absorbed orally so they are not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants.
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: Maybe acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
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