Bisoprolol (As Fumarate)

Mechanism of Action
Blocks response to beta-adrenergic stimulation, cardioselective for beta-1 at low doses with little or no effect on beta-2 receptors at doses ≤ 20 mg
Pharmacokinetics
Bioavailability: 80%
Onset of action: 1-2 hr
Excretion: Renal (50%), feces (<2%)
Contraindications
•    Sinus bradycardia, 2°/3° heart block, cardiogenic shock, overt cardiac failure, hypersensitivity, sick sinus syndrome without permanent pacemaker
Adverse Reactions
Dizziness, Insomnia, Bradyarrhythmia, Upper respiratory infection, Diarrhea, Rhinitis, Arthralgia, Cough, Dyspnea, Nausea, Pharyngitis, Sinusitis, Vomiting
Major Drug Interactions
-
Warnings
-
Recommendations for Patient
-
Pregnancy Considerations
Category: C
Breastfeeding Considerations
Excretion in milk unknown, Use caution

Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.

Send to other people