Meropenem
- Meropenem
- No Brand Name
- Solution and Powder for Injection
- 500mg
- Vial
- -
-
• Complicated Skin/Skin Structure Infections
• Complicated Intra-abdominal Infections
• Complicated Intra-abdominal Infections
Mechanism of Action
Inhibits cell-wall synthesis by binding to penicillin-binding proteins, resistant to most beta-lactamases
Pharmacokinetics
Excretion: Urine (~25% as inactive metabolites)
Contraindications
• Hypersensitivity to IV components, beta-lactams, or other drugs in this class
Adverse Reactions
Constipation, Diarrhea, Nausea or vomiting, Rash, Headache, Inflammation at injection site, Sepsis, Oral moniliasis, Bleeding, Apnea, Constipation, Glossitis, Injection-site reaction, Phlebitis or thrombophlebitis, Pruritus, Septic shock
Major Drug Interactions
-
Warnings
• To avoid development of drug resistance, drug should be used only in proven or strongly suspected bacterial infections or a prophylactic indication
• Prolonged use may result in overgrowth of nonsusceptible organisms
Recommendations for Patient
-
Pregnancy Considerations
Category: B
Breastfeeding Considerations
Drug has been reported to be excreted in human milk, no information is available on effects of drug on breast-fed child or on milk production, the developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for therapy and any potential adverse effects on breast-fed child from therapy or from the underlying maternal condition.
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Inhibits cell-wall synthesis by binding to penicillin-binding proteins, resistant to most beta-lactamases
Pharmacokinetics
Excretion: Urine (~25% as inactive metabolites)
Contraindications
• Hypersensitivity to IV components, beta-lactams, or other drugs in this class
Adverse Reactions
Constipation, Diarrhea, Nausea or vomiting, Rash, Headache, Inflammation at injection site, Sepsis, Oral moniliasis, Bleeding, Apnea, Constipation, Glossitis, Injection-site reaction, Phlebitis or thrombophlebitis, Pruritus, Septic shock
Major Drug Interactions
-
Warnings
• To avoid development of drug resistance, drug should be used only in proven or strongly suspected bacterial infections or a prophylactic indication
• Prolonged use may result in overgrowth of nonsusceptible organisms
Recommendations for Patient
-
Pregnancy Considerations
Category: B
Breastfeeding Considerations
Drug has been reported to be excreted in human milk, no information is available on effects of drug on breast-fed child or on milk production, the developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for therapy and any potential adverse effects on breast-fed child from therapy or from the underlying maternal condition.
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
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