Meglumine Compound

Mechanism of Action
Contrast enhancement 
Pharmacokinetics
Excretion: Urine, feces
Contraindications
• Hypersensitivity to diatrizoate
• Intrathecal use
• Myelography
Adverse Reactions
Arterial Thrombosis, Cardiac Arrhythmia, Brachial Plexopathy, Chest Pain, Choking Sensation, ECG Changes, Edema, Flushing, Hypertension, Hypotension, Myocardial Infarction, Venous Pain, Ventricular Fibrillation, Chills, Headache, Pallor, Nausea, Hypothyroidism, Pruritus, Skin Rash, Urticaria, Neutropenia, Anaphylactoid Reaction, Burning Sensation At Injection Site, Muscle Cramps, Sneezing, Wheezing, Conjunctival Petechiae, Lacrimation
Major Drug Interactions
-
Warnings
• Not for intrathecal use
Recommendations for Patient
-
Pregnancy Considerations
Category: C
Breastfeeding Considerations
Distributed in milk, use caution

Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: Maybe acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.

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