Ibuprofen
- Ibuprofen
- No Brand Name
- Tablet
- 400mg
- Blister
- 30 / 100 Tablets
-
• Pain and Fever
• Dysmenorrhea
• Inflammatory Disease
• Dysmenorrhea
• Inflammatory Disease
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Mechanism of Action
Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclo-oxygenase (COX) isoenzymes, COX-1 and COX-2
Pharmacokinetics
Bioavailability: 80-100%
Onset: 30-60 min
Duration: 4-6 hr
Excretion: Urine (50-60%); remainder in feces within 24 hr
Contraindications
• Hypersensitivity to Ibuprofen, other NSAIDs, aspirin, or excipients
• Perioperative pain in setting of coronary artery bypass graft (CABG) surgery
Adverse Reactions
Dizziness, Epigastric pain, Heartburn, Constipation, Nausea, Rash, Tinnitus, Edema, Fluid retention, Headache, Vomiting
Major Drug Interactions
-
Warnings
Cardiovascular risk
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase risk of serious cardiovascular thrombotic events, myocardial infarction (MI), and stroke, which can be fatal
• Risk may increase with duration of use
• Patients with existing cardiovascular disease or risk factors for such disease may be at greater risk
• NSAIDs are contraindicated for perioperative pain in setting of coronary artery bypass graft (CABG) surgery
Gastrointestinal risk
• NSAIDs increase risk of serious GI adverse events, including bleeding, ulceration, and gastric or intestinal perforation, which can be fatal
• GI adverse events may occur at any time during use and without warning symptoms
• Elderly patients are at greater risk for serious GI events
Recommendations for Patient
• If pregnant; ask a health professional before use.
• Use caution in asthma (bronchial), cardiac disease, congestive heart failure (CHF), hepatic or renal impairment, hypertension.
• Long-term administration of NSAIDs may result in renal papillary necrosis and other renal injury.
Pregnancy Considerations
Category C
Breastfeeding Considerations
Because of its extremely low levels in breastmilk, short half-life and safe use in infants in doses much higher than those excreted in breastmilk, ibuprofen is a preferred choice as an analgesic or anti-inflammatory agent in nursing mothers.
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: Maybe acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclo-oxygenase (COX) isoenzymes, COX-1 and COX-2
Pharmacokinetics
Bioavailability: 80-100%
Onset: 30-60 min
Duration: 4-6 hr
Excretion: Urine (50-60%); remainder in feces within 24 hr
Contraindications
• Hypersensitivity to Ibuprofen, other NSAIDs, aspirin, or excipients
• Perioperative pain in setting of coronary artery bypass graft (CABG) surgery
Adverse Reactions
Dizziness, Epigastric pain, Heartburn, Constipation, Nausea, Rash, Tinnitus, Edema, Fluid retention, Headache, Vomiting
Major Drug Interactions
-
Warnings
Cardiovascular risk
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase risk of serious cardiovascular thrombotic events, myocardial infarction (MI), and stroke, which can be fatal
• Risk may increase with duration of use
• Patients with existing cardiovascular disease or risk factors for such disease may be at greater risk
• NSAIDs are contraindicated for perioperative pain in setting of coronary artery bypass graft (CABG) surgery
Gastrointestinal risk
• NSAIDs increase risk of serious GI adverse events, including bleeding, ulceration, and gastric or intestinal perforation, which can be fatal
• GI adverse events may occur at any time during use and without warning symptoms
• Elderly patients are at greater risk for serious GI events
Recommendations for Patient
• If pregnant; ask a health professional before use.
• Use caution in asthma (bronchial), cardiac disease, congestive heart failure (CHF), hepatic or renal impairment, hypertension.
• Long-term administration of NSAIDs may result in renal papillary necrosis and other renal injury.
Pregnancy Considerations
Category C
Breastfeeding Considerations
Because of its extremely low levels in breastmilk, short half-life and safe use in infants in doses much higher than those excreted in breastmilk, ibuprofen is a preferred choice as an analgesic or anti-inflammatory agent in nursing mothers.
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: Maybe acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
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