Menotropins

Mechanism of Action
LH & FSH are pituitary gonadotropins that stimulate gonadal function, including spermatogenesis & ovulation 
Pharmacokinetics
Excretion: Urine
Contraindications
• Pregnancy; may cause fetal harm
• Hypersensitivity
• High levels of FSH indicating primary ovarian failure
• Presence of uncontrolled nongonadal endocrinopathies (eg, thyroid, adrenal, or pituitary disorders)
• Sex hormone dependent tumors of the reproductive tract and accessory organ
• Tumors of pituitary gland or hypothalamus
• Abnormal uterine bleeding of undetermined origin
• Ovarian cysts or enlargement of undetermined origin, not due to polycystic ovary syndrome
Adverse Reactions
 Headache , Abdominal pain, Nausea, OHSS, Injection site pain, Flushing, Dizziness, Malaise, Migraine, Breast tenderness, Hot flashes, Menstrual irregularities, Abdominal cramping/fullness, Constipation, Diarrhea, Ovarian disease, Vaginal hemorrhage, Back pain, Cough increased, Respiratory disorder, Flu-like syndrome
Major Drug Interactions
-
Warnings
• Should be administered only by physicians thoroughly experienced in fertility disorders
Recommendations for Patient
-
Pregnancy Considerations
Category: X
Breastfeeding Considerations
Not known whether drug is excreted in breast milk, use caution



Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: Maybe acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.