Colistimethate (As Sodium)

Mechanism of Action
Structurally similar to polymyxin B, colistimethate hydrolyzed to colistin in vitro or in vivo
Cationic detergent that damages bacterial cytoplasmic membrane, causing cell death
Pharmacokinetics
-
Contraindications
•    Hypersensitivity
Adverse Reactions
Dizziness, Paresthesia, Tingling of extremities and tongue
Major Drug Interactions
-
Warnings
•    Not indicated for infections by Proteus or Neisseria
Recommendations for Patient
-
Pregnancy Considerations
Category: C
Breastfeeding Considerations
Unknown, Use caution

Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.

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