Clindamycin (As Phosphate)
- Clindamycin (As Phosphate)
- No Brand Name
- Solution and Powder for Injection
- 150mg/mL
- Ampoule
- 2mL
-
• Aerobic Gram-Positive Cocci Infections
• Serious Infections Caused by Anaerobic Bacteria
• Amnionitis
• Surgical Prophylaxis
• Gangrenous Pyomyositis
• Group B Streptococcus
• Orofacial/Parapharyngeal Space Infections
• Pelvic Inflammatory Disease
• Toxic Shock Syndrome
• Serious Infections Caused by Anaerobic Bacteria
• Amnionitis
• Surgical Prophylaxis
• Gangrenous Pyomyositis
• Group B Streptococcus
• Orofacial/Parapharyngeal Space Infections
• Pelvic Inflammatory Disease
• Toxic Shock Syndrome
Mechanism of Action
Suppresses protein synthesis by binding to 50S ribosomal subunits, bacteriostatic or bactericidal depending on drug concentration, organism and infection site
Pharmacokinetics
Peak serum time: 1-3 hr (IM)
Excretion: Urine (10%), feces (~4%)
Contraindications
• Hypersensitivity to clindamycin, lincomycin, or formulation components
Adverse Reactions
Abdominal pain, Agranulocytosis, Eosinophilia (transient), Diarrhea, Fungal overgrowth, Pseudomembranous colitis, Hypersensitivity, Stevens-Johnson syndrome, Rashes, Urticaria, Hypotension, Nausea, Vomiting, Sterile abscess at IM site, Thrombophlebitis, Granulocytopenia, Neutropenia, Thrombocytopenia, Polyarthritis, Renal dysfunction
Major Drug Interactions
-
Warnings
• Clostridium difficile-associated diarrhea (CDAD) has been reported and may range in severity from mild diarrhea to fatal colitis
• May increase risk of drug-resistant bacteria if prescribed in the absence of proven or strongly suspected bacterial infection
• Not for administration as a bolus; infuse over 10-60 min
Recommendations for Patient
• Before using clindamycin, tell your doctor if you are allergic to it; or to lincomycin; or if you have any other allergies.
Pregnancy Considerations
Category B
Clindamycin should be used during first trimester of pregnancy only if clearly needed.
Breastfeeding Considerations
Clindamycin has the potential to cause adverse effects on the breastfed infant's gastrointestinal flora. If oral or intravenous clindamycin is required by a nursing mother, it is not a reason to discontinue breastfeeding, but an alternate drug may be preferred. Monitor the infant for possible effects on the gastrointestinal flora, such as diarrhea, candidiasis (thrush, diaper rash) or rarely, blood in the stool indicating possible antibiotic-associated colitis.
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: Maybe acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Suppresses protein synthesis by binding to 50S ribosomal subunits, bacteriostatic or bactericidal depending on drug concentration, organism and infection site
Pharmacokinetics
Peak serum time: 1-3 hr (IM)
Excretion: Urine (10%), feces (~4%)
Contraindications
• Hypersensitivity to clindamycin, lincomycin, or formulation components
Adverse Reactions
Abdominal pain, Agranulocytosis, Eosinophilia (transient), Diarrhea, Fungal overgrowth, Pseudomembranous colitis, Hypersensitivity, Stevens-Johnson syndrome, Rashes, Urticaria, Hypotension, Nausea, Vomiting, Sterile abscess at IM site, Thrombophlebitis, Granulocytopenia, Neutropenia, Thrombocytopenia, Polyarthritis, Renal dysfunction
Major Drug Interactions
-
Warnings
• Clostridium difficile-associated diarrhea (CDAD) has been reported and may range in severity from mild diarrhea to fatal colitis
• May increase risk of drug-resistant bacteria if prescribed in the absence of proven or strongly suspected bacterial infection
• Not for administration as a bolus; infuse over 10-60 min
Recommendations for Patient
• Before using clindamycin, tell your doctor if you are allergic to it; or to lincomycin; or if you have any other allergies.
Pregnancy Considerations
Category B
Clindamycin should be used during first trimester of pregnancy only if clearly needed.
Breastfeeding Considerations
Clindamycin has the potential to cause adverse effects on the breastfed infant's gastrointestinal flora. If oral or intravenous clindamycin is required by a nursing mother, it is not a reason to discontinue breastfeeding, but an alternate drug may be preferred. Monitor the infant for possible effects on the gastrointestinal flora, such as diarrhea, candidiasis (thrush, diaper rash) or rarely, blood in the stool indicating possible antibiotic-associated colitis.
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: Maybe acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
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